1-Boc-3-Azetidinone CAS 398489-26-4 Baricitinib Intermediate Purity >98.0% (GC) Factory

Short Description:

Chemical Name: 1-Boc-3-Azetidinone

CAS: 398489-26-4

Purity: >98.0% (GC) Assay: >98.0% (QNMR)

Appearance: Light Yellow Solid

Intermediate of Baricitinib (CAS: 1187594-09-7)

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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398489-26-4 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 1-Boc-3-Azetidinone (CAS: 398489-26-4) with high and stable quality control, an important intermediate of Baricitinib (CAS: 1187594-09-7).
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available.
Purchase 1-Boc-3-Azetidinone and Baricitinib intermediates, Please contact us by e-mail: alvin@ruifuchem.com for quotation requests. Please provide quantity, purity, and any other specific requirements.

Intermediates of Baricitinib (CAS: 1187594-09-7):

Baricitinib API	CAS 1187594-09-7
1-Boc-3-Azetidinone	CAS 398489-26-4
3-Hydroxyazetidine Hydrochloride	CAS 18621-18-6
1-Boc-3-(Cyanomethylene)azetidine	CAS 1153949-11-1
2-[1-(Ethylsulfonyl)azetidin-3-ylidene]acetonitrile	CAS 1187595-85-2
2-(Azetidin-3-ylidene)acetonitrile Hydrochloride	CAS 1314910-43-4
1-(1-Ethoxyethyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester	CAS 1029716-44-6
4-(1H-Pyrazol-4-yl)-7-[[2-(Trimethylsilyl)ethoxy]methyl]-7H-Pyrrolo[2,3-d]pyrimidine	CAS 941685-27-4

398489-26-4 - Chemical Properties:

Chemical Name	1-Boc-3-Azetidinone
Synonyms	1-(tert-Butoxycarbonyl)-3-Azetidinone; tert-Butyl 3-Oxoazetidine-1-Carboxylate; 3-Oxoazetidine-1-Carboxylic Acid tert-Butyl Ester; 1-Boc-Azetidin-3-One; 1-N-Boc-3-Azetidinone; 3-Oxoazetidine, N-Boc Protected
Stock Status	In Stock, Commercial Production
CAS Number	398489-26-4
Molecular Formula	C8H13NO3
Molecular Weight	171.20 g/mol
Melting Point	49.0~52.0℃
Density	1.174±0.06 g/cm3
Store Under Inert Gas	Store Under Inert Gas
Sensitive	Moisture Sensitive
Storage Temp.	Store at 2~8℃
COA & MSDS	Available
Origin of Product	Shanghai, China
Shelf Life	24 Months From Manufacture Date if Stored Properly
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

398489-26-4 - Specifications:

Items	Specifications	Results
Appearance	Light Yellow Solid	Light Yellow Solid
400 MHz 1H NMR Spectrum	Conforms to Structure	Conforms
Melting Point	49.0~52.0℃	49.3~51.7℃
Water by Karl Fischer	<0.50%	0.05%
Residue on Ignition	<0.20%	0.12%
Purity / Analysis Method	>98.0% (GC Area)	99.7%
Largest Unknown Impurity	<1.00%	<1.00%
Assay / Analysis Method	>98.0% (QNMR, w/w%)	98.3%
Conclusion	The product has been tested and complies with the given specifications
Usage	Intermediate of Baricitinib (CAS: 1187594-09-7)
Note: 1, Values of the results shown are based upon analysis of samples taken from this batch randomly. 2, Observed mass shouId be within 0.10% of expected mass.

398489-26-4 - Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

398489-26-4 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

398489-26-4 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

398489-26-4 - Risk and Safety:

Risk Codes R22 - Harmful if swallowed
R37/38 - Irritating to respiratory system and skin.
R41 - Risk of serious damage to eyes
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
UN IDs UN 3335
WGK Germany 3
HS Code 2933990099
Hazard Class IRRITANT

398489-26-4 - Application:

1-Boc-3-Azetidinone (CAS: 398489-26-4), is a unique and versatile synthetic organic compound that has been used in a wide range of scientific research applications. It is a versatile building block for the synthesis of complex molecules and it has been used in the synthesis of a variety of pharmaceuticals, including antibiotics, antivirals, and anti-cancer agents.
1-Boc-3-Azetidinone is used as a pharmaceutical intermediate, intermediate of Baricitinib (CAS: 1187594-09-7). Baricitinib (trade name Olumiant) is a drug for the treatment of rheumatoid arthritis (RA), being developed by Incyte and Eli Lilly.It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved in Europe. Patients with intolerance to one or more anti-rheumatic drugs can be treated with Baricitinib. Baricitinib can be treated as a single agent or combined with a combined treatment of methotrexate in therapy.